G protein coupled receptor structure and activation.
نویسنده
چکیده
G protein coupled receptors (GPCRs) are remarkably versatile signaling molecules. The members of this large family of membrane proteins are activated by a spectrum of structurally diverse ligands, and have been shown to modulate the activity of different signaling pathways in a ligand specific manner. In this manuscript I will review what is known about the structure and mechanism of activation of GPCRs focusing primarily on two model systems, rhodopsin and the beta(2) adrenoceptor.
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عنوان ژورنال:
- Biochimica et biophysica acta
دوره 1768 4 شماره
صفحات -
تاریخ انتشار 2007